I have used TTS, SE tuners, Power Commander and Power Vision. I was one of the original Beta testers for the Power Vision and really like it. As Firecat mentioned, your ECM will learn as you ride by reading the O2 sensors but you still are stuck with the 14.7 AFR mandated by the EPA and the other settings decided upon by Harley to meet the EPA mandated guidelines for emissions. 14.7 AFR is good for emissions but not always best for power and it generates more heat. A tuner will let you adjust those setting or load a base map developed by others to the ECM to generate more power, less heat and in some cases better mpg.
I really like the Power Vision. You can do as much or as little with it as you like.