I just did this trip this past October. The ride from Daytona to the Keys via turnpike was boring. The ride through the keys was really nice. Gorgeous blue water. Here are a few tips:
*A friend of mine highly recommended get yourself a good pair of polarized glasses. It helps with the glare of the water and really makes it pop.
*Gas is cheaper at the top of the Keys versus Key West.
*ABSOLUTELY STOP AND EAT AT Mrs Macs Kitchen. They had the best Key Lime and again was another recommendation from a friend who has made over 2 dozen trips to the Keys.
http://www.mrsmacskitchen.com/
Key West places to visit:
* If history is your thing definitely visit Ernest Hemingway's Estate and Harry Truman's Little White House.
* Sloppy Joes for a relaxed atmosphere to enjoy some lunch and entertainment. I highly suggest the nachos topped in sloppy joe since this is where this dish originated. You can't stop eating it is so good!
*Sunset at Mallory Square is a must. Just gorgeous and allot of live entertainment to be had.
* We stayed at the Merlin House one street from Duvall . They are apart of a group of historic inns.
http://www.historickeywestinns.com/the-inns/
* If you love dessert a definite stop is the Better than Sex - A Key West Dessert restaurant.
http://www.betterthansexkeywest.com/
* Great breakfast place to see the sunrise is at
http://www.southernmostbeachcafe.com/
If you want more information please let me know.